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The direct effects of exogenous hyaluronan (i.e. injections of artificial sodium hyaluronate) cannot account for its long-term benefits, as it is cleared from the joint within a few days. It appears that, through its direct effects, exogenous hyaluronan restores the ability of the joint to produce its own hyaluronan and thus returns it to a state of homeostasis (i.e. stable condition) that persists for several months.*
Evidence exists suggesting that exogenous hyaluronan may slow the destruction of cartilage*. *References available upon request.